Heterocyclic Chemistry
Heterocycles are crucial components of imortant molecules found across all facets of every day life.
This course of videos aims to provide a rigourous foundation of heterocyclic chemistry, it aims to teach you to:
1) identify and name the most commonly found and most important heterocycles;
2) work out when a heterocycle is aromatic and appreciate the different ways in which a heteroatom can contribute to aromaticity;
3) explain the reactivity and behaviour of different classes of heterocycles and substituted heterocycles;
4) devise or explain the synthesis of key heterocycles based upon a) classical heterocyclic syntheses; and b) basic functional group chemistry;
5) recognise how the structure and reactivity of heterocycles containing two or more heteroatoms correlates with heterocycles possessing a single heteroatom;
6) devise or explain the synthesis of heterocycles containing two or more heteroatoms and recognise the relationship to the syntheses of those containing a single heteroatom; and
7) appreciate the pivotal importance of heterocycles in important molecules.
- A PDF Handout to accompany thee lectures is available for download: PDF.
- All the videos have been complied to a YouTube playlist: YouTube.
- Total running time: 4 hrs 16 mins.
01: Introduction to Heterocyclic Chemistry
[06:46]
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02: Revision of Key Concepts
[14:09]
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03: Heterocycle Nomenclature
[18:47]
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05: Reactivity of 6-Membered
Aromatic Heterocycles - Part 1 [29:07]
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06: Reactivity of 6-Membered
Aromatic Heterocycles - Part 2 [16:57]
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07: Reactivity of 6-Membered
Aromatic Heterocycles - Part 3 [12:40]
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08: Reactivity of 5-Membered
Aromatic Heterocycles [19:01]
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09: General Reactivity of
Heterocycles [27:06]
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10: Strategy for Heterocycle Synthesis:
Cyclisation and Dehydration [29:39]
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11: Synthesis of Furans and Pyrroles
[14:41]
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12: Synthesis of Pyridines
[14:49]
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13: Synthesis of Isoquinolines and
Quinolines [22:39]
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14: Synthesis of Indoles
[10:25]
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15: Heterocycle Synthesis by
1,3-Dipolar Cycloaddition [11:42]
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Example Question and Solution
- A sample question based upon this material is available: PDF.
- Video suggested solution for example question: YouTube.